Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

• DOI: 10.1126/sciadv.aba1306
• Publication Date: 2020-08-05T23:21:28Z
• Authors: Ke Zou; Silvia Rouskin; Kevin Dervishi; Mark A. McCormick; Arjun Sasikumar; Changhui Deng; Zhibing Chen; Matt Kaeberlein; Rachel B. Brem; Michael Polymenis; Brian K. Kennedy; Jonathan S. Weissman; Jiashun Zheng; Qi Ouyang; Hao Li
• Keywords: 0301 basic medicine; 330; 1.1 Normal biological development and functioning; Longevity; 500; Saccharomyces cerevisiae; 530; 03 medical and health sciences; Glucose; Methionine; Underpinning research; Dietary Supplements; Genetics; Generic health relevance; Research Articles; Nutrition

Yeast cells lower their intracellular methionine level in response to glucose restriction to regulate metabolism and life span.