Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

• DOI: 10.1126/sciadv.aba1773
• Publication Date: 2020-07-15T23:15:56Z
• Authors: Sangsin Lee; Ning Ding; Yidi Sun; Tanglong Yuan; Jing Li; Qichen Yuan; Lizhong Liu; Jie Yang; Qian Wang; Anatoly B. Kolome...; Isaac B. Hilton; Erwei Zuo; Xue Gao
• Keywords: Base (topology); Substitution (logic); APOBEC3G

Engineered base editors convert the second nucleotide C to T in context of 5′-CC-3′ with high precision and targeting fidelity.