A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1

• DOI: 10.1126/sciadv.aba3418
• Publication Date: 2020-05-13T23:24:01Z
• Authors: Huaibing Jin; Zhiqiang Du; Yanjing Zhang; Judit Antal; Zongliang Xia; Yan Wang; Yang Gao; Xiaoge Zhao; Xinyun Han; Yanjun Cheng; Qianhua Shen; Kunpu Zhang; Robert E. Elder; Zsigmond Benko; Csaba Fenyvuesvolgyi; Ge Li; Dionne Rebello; Jing Li; Shilai Bao; Richard Y. Zhao; Daowen Wang
• Keywords: Wee1; Cdc25

Many animal viral proteins, e.g., Vpr of HIV-1, disrupt host mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. However, it is unknown whether plant viruses may use this mechanism in their pathogenesis. Here, we report that 17K protein, encoded barley yellow dwarf and related poleroviruses, delays G