Noninvasive, wearable, and tunable electromagnetic multisensing system for continuous glucose monitoring, mimicking vasculature anatomy

• DOI: 10.1126/sciadv.aba5320
• Publication Date: 2020-06-10T23:17:16Z
• Authors: Jessica Hanna; Moussa Bteich; Youssef Tawk; Ali H. Ramadan; Batoul Dia; Fatima A. Asadallah; Aline Eid; Rouwaida Kanj; Joseph Costantine; Assaad A. Eid
• Keywords: Blood Glucose; Wearable Electronic Devices; Blood Glucose Self-Monitoring; Diabetes Mellitus; 0202 electrical engineering, electronic engineering, information engineering; Animals; Humans; 02 engineering and technology; Research Articles; Monitoring, Physiologic; 3. Good health

Painless, needle-free, and continuous glucose monitoring sensors are needed to enhance the life quality of diabetic patients. To that extent, we propose a first-of-its-kind, highly sensitive, noninvasive glycemic wearable multisensor system. The proposed validated on serum, animal tissues, models diabetes in clinical setting. measurement results during human trials reported high correlation (>0.9) between system's physical parameters blood levels, without any time lag. accurate real-time responses attributed their unique vasculature anatomy-inspired tunable electromagnetic topologies. These apparels wirelessly sense hypo- hyperglycemic variations with fidelity. components designed simultaneously target multiple body locations, which opens door for development closed-loop artificial pancreas.