Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci

• DOI: 10.1126/sciadv.abb0333
• Publication Date: 2020-09-02T23:15:41Z
• Authors: Sari Kassem; Paolo Ferrari; Amanda L. Hughes; Julien Soudet; Oliver J. Rando; Michel Strubin
• Keywords: ddc:616; info:eu-repo/classification/ddc/570; 0301 basic medicine; Chromatin Immunoprecipitation; Transcription, Genetic; and Proteins; Biophysics; Genetics and Genomics; Cell Biology; histone exchange; Chromatin Assembly and Disassembly; Biochemistry; Chromatin; Histones; 03 medical and health sciences; ddc:570; info:eu-repo/classification/ddc/616; and Structural Biology; Amino Acids; Peptides; Promoter Regions, Genetic; Research Articles

Histone turnover during gene transcription is mediated by regulatory proteins, not the machinery.