Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

• DOI: 10.1126/sciadv.abb1112
• Publication Date: 2020-08-14T23:16:54Z
• Authors: Shuang Tian; Linzhu Su; Yong Liu; Jingjing Cao; Guang Yang; Yijin Ren; Fan Huang; Jianfeng Liu; Yingli An; Henny C. van der Mei; Henk J. Busscher; Linqi Shi
• Keywords: 0301 basic medicine; NANOCARRIERS; ARCHITECTURE; NITRIC-OXIDE; Intravital Microscopy; Polymers; PSEUDOMONAS-AERUGINOSA; EXTRACELLULAR DNA; Anti-Bacterial Agents; Mice; 03 medical and health sciences; Biofilms; NANOPARTICLES; Animals; PENETRATION; DRUG-DELIVERY; RESISTANCE; Research Articles; Micelles; STAPHYLOCOCCUS-AUREUS

Zwitterionic micelles find their own path through the body to disperse an infectious biofilm and enhance antibiotic efficacy.