Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

• DOI: 10.1126/sciadv.abb9036
• Publication Date: 2020-08-14T23:18:18Z
• Authors: Bradlee L. Heckmann; Brett J. W. Teubner; Emilio Boada-Romero; Bart Tummers; Clifford Guy; Patrick Fitzgerald; Ulrike Mayer; Simon Carding; Stanislav S. Zakh...; Thomas Wileman; Douglas R. Green
• Keywords: 0301 basic medicine; 570; Amyloid beta-Peptides; 610; tau Proteins; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Alzheimer Disease; Autophagy; Animals; Humans; Microglia; Research Articles

Mice with mutant ATG16L develop spontaneous, severe Alzheimer’s-like disease with age, despite normal autophagy.