IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

• DOI: 10.1126/sciadv.abb9888
• Publication Date: 2021-03-17T19:16:03Z
• Authors: Jinqiang Zhang; Peijing Rong; Lijuan Zhang; Hui He; Tao Zhou; Yonghua Fan; Li Mo; Qiuying Zhao; Yue Han; Shaoyuan Li; Yifei Wang; Wan Yan; Huafu Chen; Zili You
• Keywords: Resilience

Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific microglia groups and functionally implicated behavioral responses to stress. However, role hippocampal stress resilience remains unclear. We identified interleukin 4 (IL4)-driven characterized high expression Arg1, which critical maintaining resistance. Decreasing Arg1+ knocking down microglial IL4R suppressed enhanced vulnerability. Increasing enhancing IL4 signaling restored stress-induced depression. Brain-derived neurotrophic factor (BDNF) was found necessary for proneurogenesis effects IL4-driven microglia. Together, our findings suggest that trigger BDNF-dependent responding chronic stress, helping protect against depressive-like symptoms. These identify modulation a phenotype as treatment strategy mood disorders.