Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis
Decellularization
DOI:
10.1126/sciadv.abc3175
Publication Date:
2020-10-21T23:18:17Z
AUTHORS (11)
ABSTRACT
The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local invasion to drive metastasis. Here, we describe method study whole-tissue ECM effects from disease states associated with metastasis on cell phenotypes and identify individual proteins signaling pathways that are driving these effects. We show decellularized tumor-bearing obese mammary glands drives TNBC invasion. Proteomics gland led us full-length collagen VI as novel driver whose abundance in stroma increases body mass index human patients. Last, mechanism by which contributes via NG2-EGFR cross-talk MAPK signaling. Overall, studies demonstrate value scaffolds obtained tissues functions ECM.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (38)
CITATIONS (130)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....