Inhibition of the NLRP3 inflammasome prevents ovarian aging

• DOI: 10.1126/sciadv.abc7409
• Publication Date: 2021-01-01T20:15:23Z
• Authors: José M. Navarro-P...; Elísabet Alcocer-...; Beatriz Castejón-...; Elena Navarro-Vil...; Mónica Condés-Hervás; María Mundi-Roldan; Jordi Muntané; Antonio J. Pérez-...; Pedro Bullon; Chun Wang; Hal M. Hoffman; Alberto Sanz; Gabriel Mbalaviele; Bernhard Ryffel; Mario D. Cordero
• Keywords: 0301 basic medicine; Aging; Granulosa cells; Interleucina-1; Inflammasomes; Envejecimiento; Autofagia; Pregnancy rate; 03 medical and health sciences; NLR family, pyrin domain-containing 3 protein; Autophagy; Infertilidad; Ovarian diseases; 10. No inequality; Research Articles; Inflammation; 0303 health sciences; Células de la granulosa; Estradiol; Inflamación; Caspase 1; MCC-950; 3. Good health; Fertility; Fertilidad; Infertility; Enfermedades del ovario; Interleukin-1

Inflammation is a hallmark of aging and negatively affecting female fertility. In this study, we evaluate the role NLRP3 inflammasome in ovarian Age-dependent increased expression ovary was observed WT mice during reproductive aging. High NLRP3, caspase-1, IL-1β also granulosa cells from patients with insufficiency. Ablation improved survival pregnancy rates anti-Müllerian hormone levels autophagy ovaries. Deficiency reduced serum FSH estradiol levels. Consistent these results, pharmacological inhibition using direct inhibitor, MCC950, fertility to comparable those Nlrp3-/- mice. These results suggest that implicated age-dependent loss position as potential new therapeutic target for treatment infertility.