Inhibition of the NLRP3 inflammasome prevents ovarian aging
Aging
Granulosa cells
Interleucina-1
Inflammasomes
Envejecimiento
Autofagia
Pregnancy rate
03 medical and health sciences
NLR family, pyrin domain-containing 3 protein
Autophagy
Infertilidad
Ovarian diseases
Research Articles
Inflammation
0303 health sciences
Células de la granulosa
Estradiol
Inflamación
Caspase 1
MCC-950
3. Good health
Fertility
Fertilidad
Infertility
Enfermedades del ovario
Interleukin-1
DOI:
10.1126/sciadv.abc7409
Publication Date:
2021-01-01T20:15:23Z
AUTHORS (15)
ABSTRACT
Inflammation is a hallmark of aging and negatively affecting female fertility. In this study, we evaluate the role NLRP3 inflammasome in ovarian Age-dependent increased expression ovary was observed WT mice during reproductive aging. High NLRP3, caspase-1, IL-1β also granulosa cells from patients with insufficiency. Ablation improved survival pregnancy rates anti-Müllerian hormone levels autophagy ovaries. Deficiency reduced serum FSH estradiol levels. Consistent these results, pharmacological inhibition using direct inhibitor, MCC950, fertility to comparable those Nlrp3-/- mice. These results suggest that implicated age-dependent loss position as potential new therapeutic target for treatment infertility.
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