The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

• DOI: 10.1126/sciadv.abe2771
• Publication Date: 2021-02-24T20:15:51Z
• Authors: He Huang; Di Zhang; Yejing Weng; Kyle Delaney; Zhanyun Tang; Cong Yan; Shankang Qi; Chao Peng; Philip A. Cole; Robert G. Roeder; Yingming Zhao
• Keywords: Histones; Mammals; 0301 basic medicine; 570; 03 medical and health sciences; 3-Hydroxybutyric Acid; Lysine; 610; Animals; Acetylation; Protein Processing, Post-Translational; Research Articles

Widespread lysine β-hydroxybutyrylation plays diverse regulatory roles and is reversibly regulated by p300 and HDAC1/2.