Mutation-induced DNMT1 cleavage drives neurodegenerative disease

• DOI: 10.1126/sciadv.abe8511
• Publication Date: 2021-09-03T18:04:35Z
• Authors: Wencai Wang; Xingsen Zhao; Yanjiao Shao; Xiaoya Duan; Yaling Wang; Jialun Li; Jiwen Li; Dali Li; Xuekun Li; Jiemin Wong
• Keywords: DNMT1; Mutant protein; Cleavage (geology)

Specific mutations within the replication foci targeting sequence (RFTS) domain of human DNMT1 are causative two types adult-onset neurodegenerative diseases, HSAN1E and ADCA-DN, but underlying mechanisms largely unknown. We generated