Synthetic auxotrophy remains stable after continuous evolution and in coculture with mammalian cells

• DOI: 10.1126/sciadv.abf5851
• Publication Date: 2021-07-02T19:18:48Z
• Authors: Aditya M. Kunjapur; Michael G. Napoli...; Eriona Hysolli; Karen Noguera; Evan M. Appleton; Max G. Schubert; Michaela A. Jones; Siddharth Iyer; Daniel J. Mandell; George M. Church
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Research Articles

A synthetic auxotroph does not escape from biocontainment after evolution, demonstrating that life does not always find a way.