A brain proteomic signature of incipient Alzheimer’s disease in youngAPOEε4 carriers identifies novel drug targets

• DOI: 10.1126/sciadv.abi8178
• Publication Date: 2021-11-10T18:55:52Z
• Authors: Jackson A. Roberts; Vijay R. Varma; Yang An; Sudhir Varma; Julián Candia; Giovanna Fantoni; Vinod Tiwari; Carlos Anerillas; Andrew Williamson; Atsushi Saito; Tina Loeffler; Irene Schilcher; Ruin Moaddel; Mohammed Khadeer; Jacqueline Lovett; Toshiko Tanaka; Olga Pletnikova; Juan C. Troncoso; David A. Bennett; Marilyn S. Albert; Kaiwen Yu; Mingming Niu; Vahram Haroutunian; Bin Zhang; Junmin Peng; Deborah L. Croteau; Susan M. Resnick; Myriam Gorospe; Vilhelm A. Bohr; Luigi Ferrucci; Madhav Thambisetty
• Keywords: Apolipoprotein E; Drug target

Brain proteins altered in young APOE ε4 carriers are found decades later Alzheimer’s disease and present novel drug targets.