Novel suction-based in vivo cutaneous DNA transfection platform

• DOI: 10.1126/sciadv.abj0611
• Publication Date: 2021-11-05T17:57:36Z
• Authors: Emran O. Lallow; Nandita C. Jhumur; Ijaz Ahmed; Sagar B. Kudchodkar; Christine C. Roberts; Moonsup Jeong; Juliet M. Melnik; Sarah H. Park; Kar Muthumani; Jerry W. Shan; Jeffrey D. Zahn; David I. Shreiber; Jonathan P. Singer; Young K. Park; Joel N. Maslow; Hao Lin
• Keywords: Male; 0301 basic medicine; COVID-19 Vaccines; SARS-CoV-2; COVID-19; DNA; Suction; Administration, Cutaneous; Transfection; Rats; 3. Good health; 03 medical and health sciences; Vaccines, DNA; Animals; Biomedicine and Life Sciences; Skin

Suction-mediated cutaneous DNA uptake yielded high in vivo efficiency and thus provides an alternative transfection platform.