Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features

• DOI: 10.1126/sciadv.abk2872
• Publication Date: 2021-12-08T18:55:18Z
• Authors: Cristian Thom; Janosch Ehrenmann; Santiago Vacca; Yann Waltenspühl; Jendrik Schöppe; Ohad Medalia; Andreas Plückthun
• Keywords: Tachykinin receptor 1

Neuropeptide-bound NK 1 R:G protein complex structures explain mechanisms ranging from insurmountable antagonism to activation.