Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

• DOI: 10.1126/sciadv.abl4024
• Publication Date: 2021-12-08T18:55:18Z
• Authors: Ping Gu; Xiaoyan Hui; Qiantao Zheng; Yuan Gao; Leigang Jin; Weimin Jiang; Changsheng Zhou; Tianxia Liu; Yu Huang; Qing Liu; Tao Nie; Yanfang Wang; Yu Wang; Jianguo Zhao; Aimin Xu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Biomedicine and Life Sciences

The mitochondrial protein UCP1 has potent therapeutic effects on vascular inflammation and atherosclerosis.