Tracking the immune response by MRI using biodegradable and ultrasensitive microprobes

• DOI: 10.1126/sciadv.abm3596
• Publication Date: 2022-07-13T17:58:47Z
• Authors: Sara Martinez de ...; Charlene Jacqmarcq; Mikael Naveau; Manuel Navarro-Ov...; Swannie Pedron; Alexandre Adam; Barbara Freis; Stephane Allouche; Didier Goux; Sarah Razafindrakoto; Florence Gazeau; Damien Mertz; Denis Vivien; Thomas Bonnard; Maxime Gauberti
• Keywords: Superparamagnetism; Biocompatibility; MRI contrast agent; Magnetite Nanoparticles

Molecular magnetic resonance imaging (MRI) holds great promise for diagnosis and therapeutic monitoring in a wide range of diseases. However, the low intrinsic sensitivity MRI to detect exogenous contrast agents lack biodegradable microprobes have prevented its clinical development. Here, we synthetized agent molecular based on previously unknown mechanism self-assembly catechol-coated magnetite nanocrystals into microsized matrix-based particles. The resulting (M3P particles) carry up 40,000 times higher amounts superparamagnetic material than classically used nanoparticles while preserving favorable biocompatibility excellent water dispersibility. After conjugation monoclonal antibodies, targeted M3P display high specificity inflammation vivo brain, kidneys, intestinal mucosa. payload material, toxicity profile, short circulation half-life, widespread reactivity particles provides promising platform translation immuno-MRI.