Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses

Neuroligin Silent synapse Postsynaptic density Nanoclusters Neurotransmitter receptor Neurexin Long-term depression
DOI: 10.1126/sciadv.abo4173 Publication Date: 2022-06-15T17:53:55Z
ABSTRACT
The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity synaptic transmission. However, mechanisms controlling nanoscale in vivo remain incompletely understood. Here, we deconstructed role neuroligin-3 (Nlgn3), a adhesion molecule linked to autism, organizing AMPA-type glutamate calyx Held synapse. Deletion
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