Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses
Neuroligin
Silent synapse
Postsynaptic density
Nanoclusters
Neurotransmitter receptor
Neurexin
Long-term depression
DOI:
10.1126/sciadv.abo4173
Publication Date:
2022-06-15T17:53:55Z
AUTHORS (7)
ABSTRACT
The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity synaptic transmission. However, mechanisms controlling nanoscale in vivo remain incompletely understood. Here, we deconstructed role neuroligin-3 (Nlgn3), a adhesion molecule linked to autism, organizing AMPA-type glutamate calyx Held synapse. Deletion
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (80)
CITATIONS (29)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....