Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses

• DOI: 10.1126/sciadv.abo4173
• Publication Date: 2022-06-15T17:53:55Z
• Authors: Ying Han; Ran Cao; Liming Qin; Lulu Y. Chen; Ai-Hui Tang; Thomas C. Südhof; Bo Zhang
• Keywords: Neuroligin; Silent synapse; Postsynaptic density; Nanoclusters; Neurotransmitter receptor; Neurexin; Long-term depression

The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity synaptic transmission. However, mechanisms controlling nanoscale in vivo remain incompletely understood. Here, we deconstructed role neuroligin-3 (Nlgn3), a adhesion molecule linked to autism, organizing AMPA-type glutamate calyx Held synapse. Deletion