Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein

• DOI: 10.1126/sciadv.abo6094
• Publication Date: 2022-04-27T17:58:00Z
• Authors: Gang Wang; Huomiao Ran; Jie Fan; Nancy P. Keller; Zhiguo Liu; Fan Wu; Wen-Bing Yin
• Keywords: Secondary metabolite

Microbial communication has attracted notable attention as an indicator of microbial interactions that lead to marked alterations secondary metabolites (SMs) in varied environments. However, the mechanisms responsible for SM regulation are not fully understood, especially fungal-fungal interactions. Here, cocultivation endophytic fungus Epicoccum dendrobii with model Aspergillus nidulans and several other filamentous fungi triggered widespread alteration SMs. Multiple silent biosynthetic gene clusters A. were activated by transcriptome metabolome analysis. Unprecedentedly, deletion replacement proved a partial loss-of-function VeA1 protein, but VeA, was associated changes both fumigatus during cocultivation. required transcription factor SclB velvet complex members LaeA VelB producing aspernidines representative formation SMs . This study provides new insights into mechanism trigger metabolic