Ring-stacked capsids of white spot syndrome virus and structural transitions with genome ejection

White spot syndrome Cryo-Electron Microscopy
DOI: 10.1126/sciadv.add2796 Publication Date: 2023-02-22T18:57:21Z
ABSTRACT
White spot syndrome virus (WSSV) is one of the largest DNA viruses and major pathogen responsible for white in crustaceans. The WSSV capsid critical genome encapsulation ejection exhibits rod-shaped oval-shaped structures during viral life cycle. However, detailed architecture structural transition mechanism remain unclear. Here, using cryo-electron microscopy (cryo-EM), we obtained a cryo-EM model were able to characterize its ring-stacked assembly mechanism. Furthermore, identified an from intact virions analyzed capsids induced by high salinity. These transitions, which decrease internal pressure, always accompany release mostly eliminate infection host cells. Our results demonstrate unusual offer insights into pressure-driven release.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (65)
CITATIONS (9)