Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression

• DOI: 10.1126/sciadv.add8977
• Publication Date: 2023-01-27T19:02:24Z
• Authors: Chao Liu; Min Zhang; Xinlong Yan; Yanli Ni; Yandong Gong; Cong Wang; Xiaoling Zhang; Lingfei Wan; Hui Yang; Chen Ge; Yunqiao Li; Wenxue Zou; Rui Huang; Xiaohui Li; Bing Sun; Bing Liu; Jinbo Yue; Jinming Yu
• Keywords: Tumor progression

Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge the transcriptional programs underlying each stage CESC lacking, important questions remain. We performed single-cell RNA sequencing 76,911 individual cells from 13 samples cervical tissues at various malignancy, illuminating tumorigenic trajectory epithelial revealing key factors involved in In addition, we found significant correlations between abundance specific myeloid, lymphoid, endothelial populations progression CESC, which were also associated patients' prognosis. Last, demonstrated tumor-promoting function matrix cancer-associated fibroblasts via NRG1-ERBB3 pathway CESC. This study provides valuable resource deeper insights into progression, helpful refining diagnosis for design optimal treatment strategies.