A bistable and reconfigurable molecular system with encodable bonds

• DOI: 10.1126/sciadv.ade3003
• Publication Date: 2022-11-18T16:51:10Z
• Authors: Chunyang Zhou; Donglei Yang; Sebastian Sensale; Pranav Sharma; Dongfang Wang; Lei Yu; Gaurav Arya; Yonggang Ke; Pengfei Wang
• Keywords: Reconfigurability; Bistability

Molecular systems with ability to controllably transform between different conformations play pivotal roles in regulating biochemical functions. Here, we report the design of a bistable DNA origami four-way junction (DOJ) molecular system that adopts two distinct stable controllable reconfigurability by using conformation-controlled base stacking. Exquisite control over DOJ's conformation and transformation is realized programming stacking bonds (quasi-blunt-ends) within induce prescribed coaxial neighboring arms. A specific DOJ may be achieved encoding binary sequences based on thermodynamic calculations. Dynamic transformations various are environmental stimulations reprogram codes. This work provides useful platform for constructing self-assembled nanostructures nanomachines insights future artificial increasing complexity reconfigurability.