Human voltage-gated Na + and K + channel properties underlie sustained fast AP signaling

• DOI: 10.1126/sciadv.ade3300
• Publication Date: 2023-10-12T17:57:22Z
• Authors: René Wilbers; Verjinia D. Metod...; Sarah Duverdin; Djai B. Heyer; Anna A. Galakhova; Eline J. Mertens; Tamara D. Versluis; Johannes C. Baayen; Sander Idema; David P. Noske; Niels Verburg; Ronald B. Willemse; Philip C. de Witt...; Maarten H. P. Kole; Christiaan P. J. ...; Huibert D. Mansve...; Natalia A. Goriou...
• Keywords: Subthreshold conduction

Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet unexpectedly fast input-output properties: Rapid subthreshold synaptic membrane potential changes reliably encoded in timing of action potentials (APs). Here, we tested whether biophysical properties voltage-gated sodium (Na