Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression

• DOI: 10.1126/sciadv.adf6927
• Publication Date: 2023-06-14T17:57:40Z
• Authors: Caiqi Cheng; Qian Cong; Yuchen Liu; Yizhong Hu; Guoyan Liang; Kevin Marc Manqui...; Yingzi Yang
• Keywords: Notochord; Floor plate; Mechanotransduction; FOXA2; Morphogen; Neurulation

Correct notochord and neural tube (NT) formation is crucial to the development of central nervous system midline structures. Integrated biochemical biophysical signaling controls embryonic growth patterning; however, underlying mechanisms remain poorly understood. Here, we took opportunities marked morphological changes during NT identified both necessary sufficient roles Yap, a key mechanosensor mechanotransducer, in activation floor plate, ventral centers that pattern dorsal-ventral axis surrounding tissues. We showed Yap by gradient mechanical stress tissue stiffness induces