Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors

• DOI: 10.1126/sciadv.adg0666
• Publication Date: 2023-08-02T17:57:30Z
• Authors: Xun Tu; Anant Jain; Paula Parra Bueno; Helena Decker; Xiaodan Liu; Ryohei Yasuda
• Keywords: Dendrite (mathematics); Homeostatic plasticity

The insulin superfamily of peptides is essential for homeostasis as well neuronal plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 2 (IGF1 IGF2) are differentially expressed in hippocampal neurons released an activity-dependent manner. Using a new fluorescence resonance energy transfer sensor IGF1 receptor (IGF1R) with two-photon lifetime imaging, find the release triggers rapid local autocrine IGF1R activation on same spine more than several micrometers along stimulated dendrite, regulating plasticity activated CA1 pyramidal neurons. In CA3 neurons, IGF2, instead IGF1, responsible synaptic plasticity. Thus, our study demonstrates cell type-specific roles IGF2 mechanism mediated by synthesis signaling IGF