Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development

• DOI: 10.1126/sciadv.adg8126
• Publication Date: 2023-11-15T18:58:28Z
• Authors: Justin Malin; Gustavo Ulises Ma...; Yongge Zhao; Susannah C. Shissler; Jennifer E. Cowan; Yi Ding; Abigail Morales-S...; Masaki Ishikawa; Marieke Lavaert; Arundhoti Das; Donna Butcher; Andrew C. Warner; Melissa Kallarakal; Jingqiu Chen; Noemi Kedei; Michael Kelly; Lauren R. Brinster; David Allman; Avinash Bhandoola
• Keywords: Mice, Inbred C57BL; Mice; Thymocytes; Gene Expression Regulation; Animals; Cell Differentiation; Epithelial Cells; Biomedicine and Life Sciences; Thymus Gland; Chromatin

Thymic epithelial cells (TEC) control T cell development and play essential roles in establishing self-tolerance. By using