A single-cell multi-omic atlas spanning the adult rhesus macaque brain
Rhesus macaque
Brain atlas
Cell type
Human brain
DOI:
10.1126/sciadv.adh1914
Publication Date:
2023-10-12T17:57:22Z
AUTHORS (17)
ABSTRACT
Cataloging the diverse cellular architecture of primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas rhesus macaque brain. Together, profiled 2.58 M transcriptomes 1.59 epigenomes from single nuclei sampled 30 regions across adult Cell composition differed extensively brain, revealing signatures region-specific functions. We also identified 1.19 candidate regulatory elements, many previously unidentified, allowing us to explore landscape cis-regulatory grammar neurological risk cell type–specific manner. Altogether, this multi-omic provides an open resource investigating evolution human identifying novel targets interventions.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (128)
CITATIONS (25)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....