A single-cell multi-omic atlas spanning the adult rhesus macaque brain

Rhesus macaque Brain atlas Cell type Human brain
DOI: 10.1126/sciadv.adh1914 Publication Date: 2023-10-12T17:57:22Z
ABSTRACT
Cataloging the diverse cellular architecture of primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas rhesus macaque brain. Together, profiled 2.58 M transcriptomes 1.59 epigenomes from single nuclei sampled 30 regions across adult Cell composition differed extensively brain, revealing signatures region-specific functions. We also identified 1.19 candidate regulatory elements, many previously unidentified, allowing us to explore landscape cis-regulatory grammar neurological risk cell type–specific manner. Altogether, this multi-omic provides an open resource investigating evolution human identifying novel targets interventions.
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