Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition

• DOI: 10.1126/sciadv.adh7828
• Publication Date: 2023-08-02T17:57:30Z
• Authors: Huizhen Ma; Xiaoning Zhang; Ling Liu; You Huang; Si Sun; Ke Chen; Qi Xin; Pengfei Liu; Yuxing Yan; Yili Wang; Yuan Li; Haile Liu; Ruoli Zhao; Kexin Tan; Xinzhu Chen; Xun Yuan; Yonghui Li; Ying Liu; Haitao Dai; Changlong Liu; Hao Wang; Xiao-Dong Zhang
• Keywords: Mice; Imaging, Three-Dimensional; Microscopy, Fluorescence; Optical Imaging; Animals; Physical and Materials Sciences; Gold; Cisplatin; 01 natural sciences; Fluorescent Dyes; 0104 chemical sciences

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.