AI-aided geometric design of anti-infection catheters

• DOI: 10.1126/sciadv.adj1741
• Publication Date: 2024-01-03T18:58:17Z
• Authors: Tingtao Zhou; Xuan Wan; Daniel Zhengyu Huang; Zongyi Li; Zhiwei Peng; Anima Anandkumar; John F. Brady; Paul W. Sternberg; Chiara Daraio
• Keywords: Bacterial colony

Bacteria can swim upstream in a narrow tube and pose clinical threat of urinary tract infection to patients implanted with catheters. Coatings structured surfaces have been proposed repel bacteria, but no such approach thoroughly addresses the contamination problem Here, on basis physical mechanism swimming, we propose novel geometric design, optimized by an artificial intelligence model. Using