Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2

• DOI: 10.1126/sciadv.adk9076
• Publication Date: 2024-05-15T18:00:27Z
• Authors: Dorien Pastoors; Marije Havermans; Roger Mulet-Lazaro; Duncan Brian; Willy Noort; Julius Grasel; Remco Hoogenboezem; Leonie Smeenk; Jeroen A. A. Demmers; Michael D. Milsom; Tariq Enver; Richard W. J. Groen; Eric Bindels; Ruud Delwel
• Keywords: hematology; leukemia; MDS1 and EVI1 Complex Locus Protein; 3. Good health; alphafold; DNA-Binding Proteins; Leukemia, Myeloid, Acute; Alcohol Oxidoreductases; Mice; Cell Transformation, Neoplastic; proteomics; SDG 3 - Good Health and Well-being; Cell Line, Tumor; Humans; Animals; chromatin; Biomedicine and Life Sciences; Co-Repressor Proteins; transcription factor; Protein Binding; Cell Proliferation; Transcription Factors

Acute myeloid leukemia (AML) driven by the activation of