Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk

• DOI: 10.1126/sciadv.adr0377
• Publication Date: 2025-01-17T18:58:55Z
• Authors: Lang Li; Hao Tian; Liulin Wu; Na Chen; Qiao Zhang; Lin Chen; Kai Zhu; Lin Lin; Xi Chen; Lang He; Min Liu; Wenyan Zhao; Yang Su; Juan Yan; Xingli Zhao; Xin Zhou; Zhenhua Zhou; Wen Zeng

The body weight–based thrombolytic medication strategy in clinical trials shows critical defects recanalization rate and post-thrombolysis hemorrhage. Methods for perceiving thrombi heterogeneity of thrombolysis resistance is urgently needed precise thrombolysis. Here, we revealed the relationship between thrombin created an artificial biomarker-based nano-patrol system with robotic functional logic to perceive report thrombi. nano-patrols are contrallable able accomplish resistance-matched personalized therapy according feedback signal from biomarkers. This depicted more enhanced efficiency (elevated by 25%) than alteplase mini pig model achieved thrombotic where encountered failure. Moreover, remarkably reduced infarct volume hemorrhagic transformation risk (0.12-fold alteplase) cerebral thrombosis. Therefore, developed a unique tool diagnosing achieving