Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling

• DOI: 10.1126/sciadv.adr7208
• Publication Date: 2025-04-09T17:58:41Z
• Authors: Ping Sun; Zhaowenbin Zhang; Fei Gao; Chen Yang; Ge Mang; Shuai Fu; Jiawei Tian; Jiang Chang
• Keywords: Dilated Cardiomyopathy

Inflammatory dilated cardiomyopathy (iDCM) represents a severe immune-related condition provoked by the progression of myocarditis. In patients suffering from myocarditis, vicious cycle inflammation orchestrated CD4 + T cells, neutrophils, and fibroblasts is culprit that drives deterioration myocarditis into iDCM. This study designed composite microneedles ion solutions using calcium silicate bioceramics, which deliver SiO 3 2− directly myocardial tissue or indirectly via systemic circulation. These interventions modulate cell microenvironment regulating T/T helper 17 (T H 17) cells their interactions with neutrophils through forkhead box O (FOXO) signaling pathway. Specifically, inhibits hyperdifferentiation to FOXO1 neutrophil extracellular traps as well myofibroblasts FOXO3, thereby ultimately disrupting subsequent fibrotic lesions in discovery indicates biomaterial-based strategy may have great potential for treatment