In situ structural-functional synchronous dissection of dynamic neuromuscular system via an integrated multimodal wearable patch

• DOI: 10.1126/sciadv.ads1486
• Publication Date: 2025-01-08T18:59:23Z
• Authors: Hang Zhao; Weicen Chen; Yuanheng Li; Hailiang Wang; Hanfei Li; Tengfei Li; Fei Han; Jing Sun; Laixin Huang; Xinhao Peng; Jianzhong Chen; Yihang Yang; Xin Qiu; Yan Liu; Huan Yu; Wen Hou; Qingsong Li; Guibing Fu; Chao You; Xijian Liu; Fei Li; Xiangxin Li; Guoru Zhao; Lin Wang; Peng Fang; Guanglin Li; Hairong Zheng; Meifang Zhu; Wei Yan; Qiong Tian; Teng Ma; Zhiyuan Liu

Neuromuscular abnormality is the leading cause of disability in adults. Understanding complex interplay between muscle structure and function crucial for effective treatment rehabilitation. However, substantial deformation muscles during movement (up to 40%) poses challenges accurate assessment. To address this, we developed a wearable structural-functional sensing patch (WSFP) that enables synchronous analysis function. The WSFP incorporates soft, stretchable electrode array high-performance electrophysiological monitoring with low contact impedance high stability. Its innovative design absorbs skin stress, ensuring stable adhesion flexible ultrasound transducer array, offering higher-fidelity imaging. With dynamic tissue imaging, it allows real-time visualization structure. achieves superior accuracy action recognition disease assessment compared single-modal methods, maintaining operation motion up 72 hours. This study advances neuromuscular system improves diagnostic precision.