Precision-controlled sequential drug release via electrochemical corrosion of liquid metal nanoparticles

• DOI: 10.1126/sciadv.adw6986
• Publication Date: 2025-06-11T15:24:09Z
• Authors: Jie Qi; Chao Xie; Mian Chen; Chen Hang; Lingmin Zhang; Xingyu Jiang

An electrically controlled, programmable drug delivery system offers substantial potential in personalized biomedical devices. Current methods lack precise control over amounts and sequences, which is crucial for optimizing therapy. We present a solution with molecules modified onto gallium-based liquid metal nanoparticles (LMNPs) using the electrochemical corrosion of LMNPs to controllably release drugs, allows arbitrary choice types, speed (fastest at less than 1 second), sequence customized This applies many types drugs (molecules containing amine, thiol, hydroxyl, carboxyl groups) integrated stretchable thin film can be implemented as epidermal or implantable tested platform antibiotics wound infections an antitumor subcutaneous melanoma, confirming its excellent therapeutic efficacy biocompatibility both vivo vitro tests.