Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis
0301 basic medicine
Indoleacetic Acids
Light
Arabidopsis Proteins
MAP Kinase Signaling System
Arabidopsis
Genes, Plant
Heterotrimeric GTP-Binding Proteins
GTP-Binding Protein alpha Subunits
Plant Leaves
03 medical and health sciences
Phenotype
Genes, Reporter
Mutation
Morphogenesis
Intercellular Signaling Peptides and Proteins
Guanosine Triphosphate
2,4-Dichlorophenoxyacetic Acid
Peptides
Alleles
Cell Size
Glucuronidase
DOI:
10.1126/science.1059040
Publication Date:
2002-07-27T09:52:41Z
AUTHORS (6)
ABSTRACT
The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (
GPA1
) in
Arabidopsis
, is a modulator of plant cell proliferation.
gpa1
null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of
GPA1
in
Arabidopsis
confers inducible ectopic cell division.
GPA1
overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of
GPA1
indicate that this subunit is a positive modulator of cell division in plants.
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