T Cell Receptor Signaling Precedes Immunological Synapse Formation

• DOI: 10.1126/science.1067710
• Publication Date: 2002-07-27T09:35:18Z
• Authors: Kyeong-Hee Lee; Amy D. Holdorf; Michael L. Dustin; Andrew C. Chan; Paul M. Allen; Andrey S. Shaw
• Keywords: Immunological synapse; Cell Signaling

The area of contact between a T cell and an antigen-presenting (APC) is known as the immunological synapse. Although its exact function unknown, one model suggests that it allows for receptor (TCR) clustering sustained signaling in cells many hours. Here we demonstrate TCR-mediated tyrosine kinase naı̈ve occurred primarily at periphery synapse was largely abated before mature synapses had formed. These data suggest hours TCR are not required activation. observations challenge current ideas about role