Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

Indoleamine 2,3-dioxygenase Plasmacytoid dendritic cell
DOI: 10.1126/science.1073514 Publication Date: 2002-09-12T22:02:54Z
ABSTRACT
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive constituted discrete identified by coexpression the cell-surface markers CD123 CCR6. In dendritic (DC) lineage, IDO-mediated suppressor activity was present fully mature as well immature CD123+ DCs. IDO+ DCs could also be readily detected vivo, which suggests these may represent regulatory humans.
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