Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

• DOI: 10.1126/science.1073514
• Publication Date: 2002-09-12T22:02:54Z
• Authors: David H. Munn; Madhav D. Sharma; Jeffrey R. Lee; Kanchan G. Jhaver; Theodore S. Johnson; Derin B. Keskin; Brendan Marshall; Phillip Chandler; Scott J. Antonia; Russell Burgess; Craig L. Slingluff; Andrew L. Mellor
• Keywords: Indoleamine 2,3-dioxygenase; Plasmacytoid dendritic cell

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive constituted discrete identified by coexpression the cell-surface markers CD123 CCR6. In dendritic (DC) lineage, IDO-mediated suppressor activity was present fully mature as well immature CD123+ DCs. IDO+ DCs could also be readily detected vivo, which suggests these may represent regulatory humans.