Vertebrate MicroRNA Genes

• DOI: 10.1126/science.1080372
• Publication Date: 2003-03-06T22:06:37Z
• Authors: Lee P. Lim; Margaret E. Glasner; Soraya Yekta; Christopher B. Burge; David P. Bartel
• Keywords: Likelihood Functions; 0303 health sciences; Genome; Genome, Human; Computational Biology; Takifugu; MicroRNAs; 03 medical and health sciences; Vertebrates; Caenorhabditis; RNA Precursors; Animals; Humans; Nucleic Acid Conformation; Conserved Sequence; Zebrafish

MicroRNAs (miRNAs) are an abundant class of ∼22-nucleotide (nt) noncoding RNAs, some of which are known to control the expression of other genes at the posttranscriptional level ([1–4][1]). We developed a computational procedure (MiRscan) to identify miRNA genes ([5][2]) and apply it here to