A Kinesin-like Motor Inhibits Microtubule Dynamic Instability

• DOI: 10.1126/science.1094838
• Publication Date: 2004-03-04T21:23:36Z
• Authors: Henrik Bringmann; Georgios Skiniotis; Annina Spilker; Stefanie Kandels-...; Isabelle Vernos; Thomas Surrey
• Keywords: Kinesin; Microtubule organizing center; Microtubule nucleation; Molecular motor

The motility of molecular motors and the dynamic instability microtubules are key processes for mitotic spindle assembly function. We report here that one kinesins localizes to chromosomes, Xklp1 from Xenopus laevis, could inhibit microtubule growth shrinkage. This effect appeared be mediated by a structural change in lattice. also found act as fast, nonprocessive, plus end-directed motor. integration two properties, inhibition dynamics, molecule emphasizes versatile properties kinesin family members.