A Kinesin-like Motor Inhibits Microtubule Dynamic Instability
Adenosine Triphosphatases
Centrosome
0301 basic medicine
Paclitaxel
Molecular Motor Proteins
Recombinant Fusion Proteins
Adenylyl Imidodiphosphate
Cryoelectron Microscopy
Xenopus Proteins
Microtubules
Chromosomes
Protein Structure, Tertiary
Kinetics
Xenopus laevis
03 medical and health sciences
Adenosine Triphosphate
Tubulin
Animals
Dimerization
Microtubule-Associated Proteins
Protein Binding
DOI:
10.1126/science.1094838
Publication Date:
2004-03-04T21:23:36Z
AUTHORS (6)
ABSTRACT
The motility of molecular motors and the dynamic instability of microtubules are key dynamic processes for mitotic spindle assembly and function. We report here that one of the mitotic kinesins that localizes to chromosomes, Xklp1 from
Xenopus laevis
, could inhibit microtubule growth and shrinkage. This effect appeared to be mediated by a structural change in the microtubule lattice. We also found that Xklp1 could act as a fast, nonprocessive, plus end–directed molecular motor. The integration of the two properties, motility and inhibition of microtubule dynamics, in one molecule emphasizes the versatile properties of kinesin family members.
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