Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin

0301 basic medicine Binding Sites Base Sequence Helicobacter pylori Indians, South American Molecular Sequence Data Adaptation, Biological Bacterial Adhesion ABO Blood-Group System Helicobacter Infections Evolution, Molecular 03 medical and health sciences Lewis Blood Group Antigens Phenotype Gastric Mucosa Mutation Peru Humans Adhesins, Bacterial Alleles Phylogeny Fucose
DOI: 10.1126/science.1098801 Publication Date: 2004-07-22T20:38:37Z
ABSTRACT
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (17)
CITATIONS (317)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....