Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin
0301 basic medicine
Binding Sites
Base Sequence
Helicobacter pylori
Indians, South American
Molecular Sequence Data
Adaptation, Biological
Bacterial Adhesion
ABO Blood-Group System
Helicobacter Infections
Evolution, Molecular
03 medical and health sciences
Lewis Blood Group Antigens
Phenotype
Gastric Mucosa
Mutation
Peru
Humans
Adhesins, Bacterial
Alleles
Phylogeny
Fucose
DOI:
10.1126/science.1098801
Publication Date:
2004-07-22T20:38:37Z
AUTHORS (31)
ABSTRACT
Adherence by
Helicobacter pylori
increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in
babA
sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to
babA
diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.
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