Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

• DOI: 10.1126/science.1100747
• Publication Date: 2004-11-18T21:33:51Z
• Authors: Robert Zimmermann; Juliane G. Strauss; Guenter Haemmerle; Gabriele Schoiswohl; Ruth Birner-Gruen...; Monika Riederer; Achim Lass; Georg Neuberger; Frank Eisenhaber; Albin Hermetter; Rudolf Zechner
• Keywords: Adipose triglyceride lipase; Perilipin; Catabolism; Hormone-sensitive lipase

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis obesity insulin resistance. Until now, hormone-sensitive lipase (HSL) was only enzyme known hydrolyze triglycerides mammalian tissue. Here, we report that a second enzyme, (ATGL), catalyzes initial step hydrolysis. It is interesting ATGL contains "patatin domain" common plant acyl-hydrolases. highly expressed mice humans. exhibits high substrate specificity for triacylglycerol associated with lipid droplets. Inhibition markedly decreases total acyl-hydrolase activity. Thus, HSL coordinately catabolize stored mammals.