Bone Marrow Stromal Cells Generate Muscle Cells and Repair Muscle Degeneration

• DOI: 10.1126/science.1110364
• Publication Date: 2005-07-07T20:48:21Z
• Authors: Mari Dezawa; Hiroto Ishikawa; Yutaka Itokazu; Tomoyuki Yoshihara; Mikio Hoshino; Shin-ichi Takeda; Chizuka Ide; Yo-ichi Nabeshima
• Keywords: Homeodomain Proteins; 0301 basic medicine; Muscle Cells; Gene Expression Profiling; Colforsin; Muscle Fibers, Skeletal; Mice, Nude; Bone Marrow Cells; Cell Differentiation; Cell Separation; Muscle Development; 3. Good health; Cell Fusion; Mice; 03 medical and health sciences; Mice, Inbred mdx; Animals; Humans; Cell Lineage; Fibroblast Growth Factor 2; Cells, Cultured; Bone Marrow Transplantation; Cell Proliferation

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage from human and rat general adherent MSCs with an efficiency of 89%. Induced differentiated into fibers upon transplantation degenerated muscles rats mdx-nude mice. The induced population contained Pax7-positive that contributed to subsequent regeneration repetitive damage without additional cells. These represent more ready supply myogenic than do the rare stem normally found in bone marrow.