Antisense Transcription in the Mammalian Transcriptome

• DOI: 10.1126/science.1112009
• Publication Date: 2005-09-01T21:23:40Z
• Authors: S. Katayama; Y. Tomaru; T. Kasukawa; K. Waki; M. Nakanishi; M. Nakamura; H. Nishida; C. C. Yap; M. Suzuki; J. Kawai; H. Suzuki; P. Carninci; Y. Hayashizaki; C. Wells; M. Frith; T. Ravasi; K. C. Pang; J. Hallinan; J. Mattick; D. A. Hume; L. Lipovich; S. Batalov; P. G. Engström; Y. Mizuno; M. A. Faghihi; A. Sandelin; A. M. Chalk; S. Mottagui-Tabar; Z. Liang; B. Lenhard; C. Wahlestedt
• Keywords: Sense strand; Transcription

Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of corresponding transcripts (RNA interference), as well silencing at chromatin level. Global transcriptome analysis provides evidence that large proportion genome can produce both strands, and antisense commonly link neighboring "genes" complex loci into chains linked transcriptional units. Expression profiling reveals frequent concordant sense/antisense pairs. We present experimental perturbation an RNA alter expression messenger RNAs, suggesting contributes control outputs mammals.