Alterations in 5-HT 1B Receptor Function by p11 in Depression-Like States

• DOI: 10.1126/science.1117571
• Publication Date: 2006-01-05T23:21:57Z
• Authors: Per Svenningsson; Karima Chergui; Ilan Rachleff; Marc Flajolet; Xiaoqun Zhang; Malika El Yacoubi; Jean-Marie Vaugeois; George G. Nomikos; Paul Greengard
• Keywords: Adult; Male; Mice, Transgenic; Mice; 03 medical and health sciences; 0302 clinical medicine; Animals; Humans; [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Electroconvulsive Therapy; Annexin A2; Aged; Mice, Knockout; Neurons; [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology; Behavior, Animal; Depression; Cell Membrane; Brain; Middle Aged; Antidepressive Agents; Rats; Receptor, Serotonin, 5-HT1B; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Female; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT 1B ) receptor] interacts with p11. p11 increases localization of 5-HT 1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT 1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT 1B receptor agonists and reduced behavioral reactions to an antidepressant.