Vaccinia Virus-Induced Cell Motility Requires F11L-Mediated Inhibition of RhoA Signaling
0301 basic medicine
0303 health sciences
Genes, Viral
Pyridines
Recombinant Fusion Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Phosphoproteins
Amides
Cell Line
Protein Structure, Tertiary
3. Good health
Cytoskeletal Proteins
03 medical and health sciences
Cell Movement
Morphogenesis
Animals
Humans
RNA Interference
Enzyme Inhibitors
RNA, Small Interfering
HeLa Cells
Protein Binding
Signal Transduction
DOI:
10.1126/science.1122411
Publication Date:
2006-01-19T22:08:37Z
AUTHORS (5)
ABSTRACT
RhoA signaling plays a critical role in many cellular processes, including cell migration. Here we show that the vaccinia F11L protein interacts directly with RhoA, inhibiting its by blocking interaction downstream effectors Rho-associated kinase (ROCK) and mDia. RNA interference-mediated depletion of during infection resulted an absence vaccinia-induced motility inhibition viral morphogenesis. Disruption binding site F11L, which resembles ROCK, led to identical phenotype. Thus, is required for both morphogenesis virus-induced motility.
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CITATIONS (105)
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