SV2 Is the Protein Receptor for Botulinum Neurotoxin A

• DOI: 10.1126/science.1123654
• Publication Date: 2006-03-17T01:34:09Z
• Authors: Min Dong; Felix Yeh; William H. Tepp; Camin Dean; Eric A. Johnson; Roger Janz; Edwin R. Chapman
• Keywords: Botulinum neurotoxin; Neurotoxin

How the widely used botulinum neurotoxin A (BoNT/A) recognizes and enters neurons is poorly understood. We found that BoNT/A by binding to synaptic vesicle protein SV2 (isoforms A, B, C). Fragments of harbor toxin interaction domain inhibited from neurons. SV2A SV2B knockout hippocampal was abolished restored expressing SV2A, SV2B, or SV2C. Reduction expression in PC12 Neuro-2a cells also entry BoNT/A, which could be isoforms. Finally, mice lacked an isoform (SV2B) displayed reduced sensitivity BoNT/A. Thus, acts as receptor for