Netrins Promote Developmental and Therapeutic Angiogenesis

• DOI: 10.1126/science.1124704
• Publication Date: 2006-06-30T10:31:42Z
• Authors: Brent D. Wilson; Masaaki Ii; Kye Won Park; Arminda Suli; Lise K. Sorensen; Fréderic Larrieu...; Lisa D. Urness; Wonhee Suh; Jun Asai; Gerhardus A.H. Kock; Tina Thorne; Marcy Silver; Kirk R. Thomas; Chi-Bin Chien; Douglas W. Losordo; Dean Y. Li
• Keywords: Netrin; Ephrin

Axonal guidance and vascular patterning share several cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, tube formation of human endothelial cells vitro this stimulation is independent known receptors. Suppression netrin1a messenger RNA zebrafish inhibits sprouting, implying a proangiogenic role for during vertebrate development. also show accelerate neovascularization an vivo model ischemia they reverse neuropathy vasculopathy diabetic murine model. propose attractive neural functions offer unique therapeutic potential.