Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13

• DOI: 10.1126/science.1135344
• Publication Date: 2007-01-12T12:48:04Z
• Authors: Heather J. Melichar; Kavitha Narayan; Sandy D. Der; Yoshiki Hiraoka; Noemie Gardiol; Gregoire Jeannet; Werner Held; Cynthia A. Chambers; Joonsoo Kang
• Keywords: TCF4; Cell fate determination

alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as gammadelta-specific gene immune system. Using transgenic mice, we showed that transcription factor promotes cell development while opposing differentiation. Conversely, mice deficient expression exhibited impaired of not cells. One mechanism SOX13 function is inhibition signaling by developmentally important Wnt/T (TCF) pathway. Our data thus reveal dominant pathway developmental fate these two lineages lymphocytes.