NOV (CCN3) Functions as a Regulator of Human Hematopoietic Stem or Progenitor Cells

• DOI: 10.1126/science.1136031
• Publication Date: 2007-04-26T20:38:02Z
• Authors: Rajeev Gupta; Dengli Hong; Francisco Iborra; Samantha Sarno; Tariq Enver
• Keywords: Progenitor; Hematopoietic stem cell

Clinically successful hematopoietic cell transplantation is dependent on stem and progenitor cells. Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov, CCN3) as being essential for their functional integrity. Nov expression restricted to primitive (CD34) compartments of umbilical vein cord blood, its knockdown in these cells by lentivirus-mediated RNA interference abrogates function vitro vivo. Conversely, forced addition recombinant both enhance and/or activity. Taken together, our results (CCN3) a regulator human or